
Well, you've lived with
your SIGNIFICANT other for some time.
The Big Bang Theory Season 10, Episode 4

...with his dating a woman
whose most SIGNIFICANT achievement...
The Big Bang Theory Season 3, Episode 11

If I had another SIGNIFICANT aspect
of my life...
The Big Bang Theory Season 2, Episode 3

I brought SIGNIFICANT assets
into the relationship too.
The Big Bang Theory Season 8, Episode 6

last words are usually
as SIGNIFICANT as first words.
Game of Thrones Season 1, Episode 4